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Mupen64Plus is a cross-platform plugin-based N64 emulator which is capable of accurately playing many games. Included are four MIPS R4300 CPU emulators, with dynamic recompilers for 32-bit x86 and 64-bit amd64 systems, and necessary plugins for audio, graphical rendering (RDP), signal co-processor (RSP), and input. There is 1 included OpenGL video plugin, called RiceVideo. There are 3 other excellent video plugins being maintained by wahrhaft, called Arachnoid, Glide64, and Z64.
brew install mupen64plus
This formula has no dependencies.